I like the layout because it appears to solve both the class B dry bathroom issue, and the disturbing your copilot in the middle of the night going to the toilet issue, with a simple, functional, floor plan.
Questions would include, but are not limited to, can the bed be easily made into a queen/king configuration, and does the sink/range/stove counter space using approximately half of the side door opening, present any issues? Maybe someone with that chassis can supply some insight, knowing the physical dimensions of the side door? Will entrance and egress be a problem?
My only other concern, which will likely kill any chance of an average person ever owning one, will be the probable mega-price tag.
The toilet comes with a three point seat belt harness, so it appears it is NHTSA compliant.