Generally, no. But I'll let others respond with more experience. Some have noted that certain tunnels and ferries require propane to be turned off. Otherwise, it's always recommended practice for propane to be turned off when you are at a gas station. I assume because an active pilot light burner on, say, a fridge could be dangerous with gasoline fumes in the pump vicinity. The main argument against having it continually on centers on the danger if you are in a substantial accident where a LP line in your RV system could be severed, allowing propane to escape in an uncontrolled manner where an engine fire or spark could ignite it. I've driven with it on and with it off, using 12v. For me it depends on where I'm driving and for how long.